Abstract
Introduction: Although limited information is available about the pathophysiology of knee osteoarthritis (OA) disease in relation with oxidative stress, there is a paucity of satisfactory explanation regarding the alteration in the level of antioxidant enzymes and lipid peroxidation with severity of knee OA. Aim: To estimate the levels of antioxidant enzymes and malondialdehyde (MDA) in the knee OA patients of different KL grade and to determine the variation in their levels with severity of disease. Materials and Methods: Antioxidant enzyme status (superoxide dismutase and ceruloplasmin) and malondialdehyde levels were measured in 150 knee OA patients (35-65 years), by using standard methods. On the basis of KL grading scale Knee OA patients were categorized into three groups (n=50 in each group) and statistically compared it with that of 50 healthy controls by using student’s t-test. Results: Erythrocyte superoxide dismutase activity was significantly low in Group II (P = Conclusion: Study findings indicate that alteration in antioxidant enzyme status and increased production of MDA are excellent marker of oxidative stress in different grades of knee OA patients. Thus, the diet rich in antioxidant or antioxidant supplementation could be beneficial in delaying the progressive destruction of articular cartilage process and serve as a preventive strategy in field of knee OA management. Keywords: Superoxide dismutase, ceruloplasmin, free radicals, Malondialdehyde, Oxidative stress.
Highlights
Limited information is available about the pathophysiology of knee osteoarthritis (OA) disease in relation with oxidative stress, there is a paucity of satisfactory explanation regarding the alteration in the level of antioxidant enzymes and lipid peroxidation with severity of knee OA
Radiographic knee osteoarthritis was defined according to Kellgren Lawrence (KL) grading scale[3] and the patients were divided into 3 groups of 50 each on the basis of KL grading scale of II to IV. 50 healthy subjects were taken from the hospital staff and their relatives included as control
Marked alteration was observed in serum MDA levels (11.31%, 38.32% and 54.01% high) in all patient groups i.e. KL grade II, III and IV knee OA patients compared to healthy controls
Summary
Limited information is available about the pathophysiology of knee osteoarthritis (OA) disease in relation with oxidative stress, there is a paucity of satisfactory explanation regarding the alteration in the level of antioxidant enzymes and lipid peroxidation with severity of knee OA. Aim: To estimate the levels of antioxidant enzymes and malondialdehyde (MDA) in the knee OA patients of different KL grade and to determine the variation in their levels with severity of disease. Materials and Methods: Antioxidant enzyme status (superoxide dismutase and ceruloplasmin) and malondialdehyde levels were measured in 150 knee OA patients (35-65 years), by using standard methods. On the basis of KL grading scale Knee OA patients were categorized into three groups (n=50 in each group) and statistically compared it with that of 50 healthy controls by using student’s t-test. Conclusion: Study findings indicate that alteration in antioxidant enzyme status and increased production of MDA are excellent marker of oxidative stress in different grades of knee OA patients. This scale involves the following grades:- grade 0: normal; grade 1: doubtful narrowing of joint space and possible osteophytic lipping; grade 2: definite osteophytes and possible narrowing of joint space; grade 3: moderate multiple osteophytes, definite narrowing of joints space, some sclerosis and possible deformity of bone contour; grade 4: large osteophytes, marked narrowing of joint space, severe sclerosis and definite deformity of bone contour
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