Abstract
The influence of Satureja montana extracts on several liver biochemical parameters in mice administered with carbon tetrachloride was estimated. In vivo investigation of antioxidant properties of S. montana extracts encompassed monitoring of biochemical parameters (derived from liver homogenate and blood hydrolyzate) and examination of potential hepatoprotective effect after intoxication with carbon tetrachloride. Biochemical tests included determination of activity of several antioxidant enzymes: xanthine oxidase, catalase, peroxidase, glutathione peroxidase, amount of reduced glutathione and intensity of lipid peroxidation. In order to obtain data about the potent hepatoprotective effect of examined extracts, the following parameters were determined: aspartate aminotrans-ferase, alanine aminotransferase, bilirubin, hepatic DNA and hydroxyprolin. Results of this study demonstrate that S. montana extracts inhibited the hepatotoxicity produced by carbon tetrachloride administration most probably through activation of physiological common defense mechanisms.
Highlights
Winter savory (Satureja montana L.) grows widely in the Balkan region and belongs to a very important family of medicinal plants, the Lamiaceae family
Results of this study demonstrate that S. montana extracts inhibited the hepatotoxicity produced by carbon tetrachloride administration most probably through activation of physiological common defense mechanisms
Significant antioxidative potential of S. montana was confirmed for essential oil, extracts obtained by conventional extraction methods, as well as extracts obtained by modern extraction methods (Cavar et al, 2008; 2014; Grosso et al, 2009; Serrano et al, 2011; Vidovicet al., 2014; Vladicet al., 2017b)
Summary
Winter savory (Satureja montana L.) grows widely in the Balkan region and belongs to a very important family of medicinal plants, the Lamiaceae family. Winter savory is an aromatic herb which is traditionally used as a spice and natural food preservative and represents a common ingredient in folk medicines for therapy of different digestive, respiratory, and urinary ailments. It is quite often used as a tonic for strengthening the immune system. Winter savory is a herb rich in carvacrol, a representative of oxidative monoterpenes which exhibits significant antioxidant potential, both in vitro and in vivo (Aeschbach et al, 1994; Aristatile et al, 2015; 2009; Guimarães et al, 2010; Slamenova et al, 2011). Based on the importance and role of carvacrol, as well as the antioxidant effect of S
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