Abstract
The present study was undertaken to investigate the antidiabetic potential of methanolic extract of Cressa cretica against streptozotocin induced diabetic rats. The halophytic plant Cressa cretica is widely used as a traditional treatment for diabetes mellitus. The methanolic extract of Cressa cretica administered orally at a dose of 100 mg/kg, for 15 days to streptozotocin induced diabetic rats. Fasting blood glucose level and change in body weight assessed in methanolic extract treated diabetic rats, were compaired with normal animal, diabetic control and standard drug treated rats. The yield of methanolic extract in Cressa cretica was found to be 16.18 %. Methanolic extract of Cressa cretica produced a significant reduction in fasting blood glucose level in streptozotocin induced diabetic rats. Significant differences were also observed in body weight by methnolic extract treated diabetic rats, when compared with diabetic control, normal control and standard drug treated rats. Methnolic extract of Cressa cretica exhibit significant anti-hyperglycemic activity in streptozotocin-induced rats. Preliminary phytochemical investigation revealed the presence of phenolic compounds and flavonoids which may be responcible for antidiabetic activity.
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