Abstract
The present study was considered to assess the antibacterial and antifungal activity of seagrass, Thalassia hemprichii extract against pathogenic bacterial and fungal strains. The seagrass T. hemprichii was collected from Gulf of Mannar, Tuticorin coast, Tamil Nadu. The collected seagrass samples were air dried and extracted with ethyl acetate, diethyl ether, acetone, methanol, ethanol and water. The acetone and ethanol crude extract of T. hemprichii exhibited broad spectrum antibacterial and antifungal activity when compared to other crude extracts. Acetone and ethanol crude extracts were further fractionated and purified using column chromatographic technique. The purified bioactive fractions (F6-A: M, F5-E) showed significant antibacterial and antifungal activity. The purity of separated fractions was analyzed using high performance liquid chromatography. The acetone extracted, column chromatographic separated fraction (F6-A: M) possess bactericidal single bioactive compound. From these results it can be concluded that seagrass T. hemprichii has a potential bioactive metabolic compound to inhibit the pathogenic bacterial and fungal strains.
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