Assessment of anti-inflammatory properties of metal nanoparticles as potential means for the correction of pathologies on the reproductive system in animals

Abstract

An urgent scientific problem is the search for means to correct inflammatory processes, especially reproductive pathologies. The article summarizes information from modern scientific sources regarding the development of drugs with pronounced anti-inflammatory properties based on nanoparticles (NPs) of metals, in particular noble ones – Silver and Gold, which exhibit antimicrobial and antioxidant effects and contribute to the reduction of inflammatory processes in various pathological conditions, which is the scientific basis for their introduction into the practice of reproductive veterinary medicine. On the other hand, the relevance of the study of the anti-inflammatory activity of NPs of rare earth elements (gadolinium, yttrium, lanthanum), which have an antibiotic effect, are able to neutralize toxic radicals, and therefore have a potential ability to correct some links in the pathogenesis of diseases of the reproductive system of inflammatory origin, is substantiated. The use of the above-mentioned metals as anti-inflammatory agents became possible due to the synthesis of compounds based on them in nanoform, as a result of the transition into which they acquire unique properties – the ability to penetrate the cell, overcome histohematiс barriers, have a large surface area and lower toxicity compared to macroergs. It should be noted that the manifestation of anti-inflammatory properties depends on the method of obtaining NPs, their physicochemical characteristics, and therefore there is a need for detailed studies of various NPs to detail the mechanisms of action and assess pharmacological activity