Abstract
Genetic risk factors are occasionally shared between different neurodegenerative diseases. Previous studies have linked ANG, a gene encoding angiogenin, to both Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). Functional studies suggest ANG plays a neuroprotective role in both PD and amyotrophic lateral sclerosis by reducing cell death. We further explored the genetic association between ANG and PD by analyzing genotype data from the International Parkinson's Disease Genomics Consortium (14,671 cases and 17,667 controls) and whole genome sequencing data from the Accelerating Medicines Partnership - Parkinson's disease initiative (AMP-PD, https://amp-pd.org/) (1,647 cases and 1,050 controls). Our analysis did not replicate the findings of previous studies and identified no significant association between ANG variants and PD risk.
Highlights
Parkinson’s disease (PD) is a neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra leading to symptoms of tremor, rigidity and slowed movement, and is the second most common neurodegenerative disease in the world
We identified a total of 168 ANG variants in the AMP-PD whole genome sequencing (WGS) data
Our analysis provides no evidence to support the hypothesis that genetic variation of ANG plays a role in PD risk or age at onset
Summary
Parkinson’s disease (PD) is a neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra leading to symptoms of tremor, rigidity and slowed movement, and is the second most common neurodegenerative disease in the world. Both sporadic and familial forms of PD exist, and much work has been done to identify the environmental and genetic risk factors behind this disease.
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