Abstract
Introduction: C-reactive protein (CRP) is present in healthy individuals in low concentrations and is routinely determined as an indicator of systemic inflammatory reaction. However, clinical significance of the very low concentrations of CRP encouraged manufacturers to develop sensitive methods that allow CRP determination in a wide range from very low to high concentrations. Such approach is of extraordinary importance in the diagnosis and follow-up of infection in preterm infants and newborns because the onset of sepsis in these patients is characterized by unspecific symptoms and is diagnosed only on the basis of laboratory results.
Highlights
C-reactive protein (CRP) is present in healthy individuals in low concentrations and is routinely determined as an indicator of systemic in ammatory reaction
Based on the obtained results, we may conclude that the Randox Full Range assay is a sensitive and reproducible reagent for determination of CRP concentration
Procjena Randox Full Range CRP u novorođenčadi Assessment of the Randox Full Range CRP assay in newborns
Summary
C-reactive protein (CRP) is present in healthy individuals in low concentrations and is routinely determined as an indicator of systemic in ammatory reaction. Clinical signi cance of the very low concentrations of CRP encouraged manufacturers to develop sensitive methods that allow CRP determination in a wide range from very low to high concentrations Such approach is of extraordinary importance in the diagnosis and followup of infection in preterm infants and newborns because the onset of sepsis in these patients is characterized by unspeci c symptoms and is diagnosed only on the basis of laboratory results. Clinical signi cance of CRP concentration increase within the reference interval induced many manufacturers to develop tests for CRP determination designed to measure very low concentrations Manufacturers of both nephelometric and turbidimetric reagents turned to latex micro-polymers to achieve the necessary sensitivity so that laboratories have at their disposal several reagent types for CRP determination: highly linear for samples analyzed for general in ammation and infection, and sensitive (SCRP) and highly sensitive (HSCRP) that are employed in neonatology and assessment of the risk of cardio- and cerebrovascular diseases. In comparison to the previously applied analytic procedure, expected advantage of the examined reagent was that the use of one reagent instead of a combination of two reagents and three applications should contribute to faster diagnosis of sepsis in such a sensitive population and to reduced measurement costs
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
