Assessment of Analgesic Activity of Two Antihypertensive Drugs

Abstract

Inflammation is an important part of the body's defense system, since it helps to remove and repair damaged tissue as well as neutralize poisonous compounds. The cascade includes increased permeability in microvessels, the attachment of circulating cells to vessels near the damage site, migration of various cell types, and the formation of new tissue and blood vessels. The analgesic and anti-inflammatory effects of rosuvastatin and telmisartan were examined in albino rats and Swiss mice. The hot plate approach regarded licking and leaping as response points. The combo group and rosuvastatin had similar analgesic efficacy. Its analgesic efficacy was significantly lower than that of a normal analgesic aspirin. Telmisartan, too, showed no analgesic effect. In this experiment, the percentage of inhibition at 120 minutes revealed that rosuvastatin and telmisartan given alone had a favourable impact on acute inflammation. Furthermore, the decrease of acute inflammation in the combination group was equivalent to that of aspirin. The data demonstrated that the capacity of the combination group to reduce chronic inflammation is equivalent to that of aspirin as an anti-inflammatory drug.