Abstract
BackgroundThe efficacy of a single 2.5 mg/kg dose of afoxolaner (NexGard®, Merial) against induced Otodectes cynotis infestations was assessed in eight afoxolaner-treated dogs, compared to eight untreated dogs.MethodsAfter O. cynotis infestations were established and confirmed by otoscopic assessments in 16 dogs, all of the dogs were included in the study and allocated to two separate treatment groups. The first group of eight ear mite-infested dogs remained untreated, while afoxolaner was administered orally to the second group of dogs at the minimum recommended dose once on Day 0. Otoscopic assessments performed on all dogs (Days -7, -2, 14 and 28) confirmed the presence or absence of live mites throughout the study. No serious adverse events were recorded throughout the study, and no adverse events were likely related to the administration of NexGard.ResultsBy Day 28, seven out of eight untreated dogs were still infested with ear mites, while only two out of eight afoxolaner-treated dogs were infested, with one and four ear mites, respectively. On Day 28, the reductions of mite counts in the afoxolaner-treated group versus those of the control dogs were 98.5% based on geometric means, and 99.4% based on arithmetic means. Significantly fewer (P < 0.05) live mites were present in the afoxolaner-treated group than the untreated group on Day 28.ConclusionThe results of this study demonstrated that a single oral administration of afoxolaner at the minimum recommended dose is highly effective (>98%) in treating dogs with induced O. cynotis infestations.
Highlights
The efficacy of a single 2.5 mg/kg dose of afoxolaner (NexGard®, Merial) against induced Otodectes cynotis infestations was assessed in eight afoxolaner-treated dogs, compared to eight untreated dogs
No serious health issues were recorded during the study, with only mild signs consistent with O. cynotis infestation observed
The percent efficacy of NexGard against induced Otodectes cynotis on Day 28 was calculated to be 98.5% based on geometric means and 99.4% based on arithmetic means (Table 3)
Summary
The efficacy of a single 2.5 mg/kg dose of afoxolaner (NexGard®, Merial) against induced Otodectes cynotis infestations was assessed in eight afoxolaner-treated dogs, compared to eight untreated dogs. The ear mite Otodectes cynotis, the causative organism of otodectic mange [1], is a very common nonburrowing, surface-living [2] acarian which infests cats, dogs and many other carnivores. Otodectes cynotis is found all over the world and primarily infests the ear canals of its host; it has been found on head, back and tail in heavy infestations [1, 2]. Secondary yeast and bacterial infections often occur in the presence of heavy ear mite infestations. Transmission of ear mites occurs by direct contact with an infested host [1,2,3], most commonly with the. Since O. cynotis is a very common parasite of dogs and cats, it is essential to find effective treatments for infested pets.
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