Abstract
Objectives: The medications of plant-based, herb-mineral, and animal sources have been used by the conventional medics to maintain well-being and care for diseases ever since ancient times. The current study aimed to evaluate the acute and subacute toxicities of the ethanolic extract of Turnera aphrodisiaca (TA) leaves in albino rats.
 Methods: The acute toxicity studies were carried out where the maximum dosage of 5000 mg/kg body mass was used. The outcome reported for 24 h and singly daily for 2 weeks. The rats were weighed and a range of interpretations, for example, behavior, lesions, mortality, or any indication of sickness, was carried out daily once throughout the study. For the subacute study, four groups of ten animals (female rats) received 10% Tween 20 in distilled H2O (as control), and 250, 500, and 1000 mg/kg of newly developed extracts, correspondingly, every 24th h orally for about 4 weeks. At the ending of every study, hematological study and biochemical parameters were assessed.
 Results: No major variations (p>0.05) were experienced in the comparative organs, body mass, hematological, biochemical parameters, and offensive malfunctions, in comparison to control, with no mortality reported. Hence, the results of the study may direct the outcome that the intermediate-period oral administration of the TA leaves for 4 weeks does not produce toxicity.
 Conclusion: Due to these results, we may well wrap up that leaves of TA extract are non-toxic in all doses considered in this study and did not created any obvious signs in the acute and subacute oral toxicity studies.
Highlights
Medicinal plants have been used in all civilizations and cultures; they have all the time performed an essential purpose globally in health-care systems
Ethanolic extract of Turnera aphrodisiaca (TA) (EETA) was dissolved in Tween 20 (10%) and delivered orally at a sole dose of 5000 mg/kg at a rate of 15 mL/kg to sexes of both rats (n=12; 6 males, 6 females), while the control group received only 10% of Tween 20 as a medium
According to results of acute toxicity studies stated that EETA was non-toxic at a dose intensity of 5000 mg/kg, subacute toxicity studies of EETA at the doses of 250, 500, and 1000 mg/kg body mass were delivered orally to four groups at each 24th h for 4 weeks and controls received the Tween 20 (10%) as a medium with similar volume
Summary
Medicinal plants have been used in all civilizations and cultures; they have all the time performed an essential purpose globally in health-care systems. The native procedures of herbal management are components of the traditions and the principal method of remedial treatment. This remediation’s, with a significant scope of efficacy, are collectively established, cheaply feasible and, typically, are the accessible foundation [1]. Medicinal plants utilized in customary medications, encompass a significant task in the safeguarding of well-being globally. Due to the undesirable effects, and as well the improvement of confrontation alongside with synthesized medicines, the role of drugs obtained from medicinal plants are fetching admired in emerging nations [2]. The newest studies encompass several remedial plants that had shown undesirable side-effects [3]
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