Abstract
<p class="Default">The <em>Psidium guajava L</em>. specie is a perennial shrub, belonging to the <em>Myrtaceae</em> family and it is popularly known as guava, its leaves are used in therapy for treating various diseases. The study aims to evaluate the antibacterial activity <em>in vitro </em>of manipulated product obtained from dried extract of the leaves of <em>P. guajava </em>L. front standard bacteria ATCC and clinical isolates. The tests were conducted on bacterial samples: <em>Staphylococcus aureus </em>(ATCC 25923), <em>Pseudomonas aeruginosa </em>(ATCC 27883), <em>Escherichia coli </em>(ATCC 25922), <em>Salmonella spp</em>, <em>Acinetobacter baumannii</em>, <em>Proteus mirabilis</em>, <em>Shigella flexneri</em>, <em>Staphylococcus epidermidis</em>, <em>Staphylococcus haemolyticus</em>, <em>Streptococcus agalactiae, Streptococcus mutans</em>. Among the tests can be mentioned phytochemical of the ethanol extract (EE), microbiological control and physical-chemical analysis of the product and microbiological tests such as agar diffusion method (wells), minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), an evaluation test of hemolytic capacity of the solution and in vitro assay cytotoxic activity were performed, . The best result of the product in the agar diffusion method was front <em>Staphylococcus epidermidis</em>, while the lower MIC and MBC were front <em>Staphylococcus aureus </em>(ATCC 25923). The product showed no hemolytic activity and no cytotoxic activity at the tested concentrations. According to the test results, it is believed on the possibility of the production of a pharmaceutical formulation derived from the dry extract of <em>Psidium guajava</em>, since it showed great antibacterial activity.</p>
Highlights
Because of the biodiversity present in different biomes in Brazil, there is growing demand for natural products by domestic and international pharmaceutical industries, which drives scientific research for natural drugs
Among the tests can be mentioned phytochemical of the P. guajava leaves ethanolic extract (EE), microbiological control and physical-chemical analysis of the product and microbiological tests such as agar diffusion method, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), an evaluation test of hemolytic capacity of the solution and in vitro assay cytotoxic activity were performed
The results of the microbiological control indicates that no contamination of the solution, since the results showed no presence of microorganism in all three culture media used since the presumptive evidence to the confirmatory test
Summary
Because of the biodiversity present in different biomes in Brazil, there is growing demand for natural products by domestic and international pharmaceutical industries, which drives scientific research for natural drugs. According to the World Health Organization, medicinal plant it is "all and any plant which has in one or more organs, substances that can be used for therapeutic purposes or are precursors semisynthetic drugs" (World Health Organization [Who], 1998). It has been proved the importance of medicinal plants to the population, especially populations with low purchasing power. These populations found simple and easy solutions due the tradition of using medicinal plants to various diseases (Vieira & Araújo, 2012). The big problem in this practice is the lack of direction for much of the population that uses this type of treatment, so that there is in some cases an aggravation of the problem, poisoning or drug interactions (Filho, 2009)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
