Abstract
Standardized case definitions are needed in decision-making regarding respiratory syncytial virus control strategies, including vaccine evaluation. A syndromic case definition comprising of "wheeze or apnea or cyanosis" could be useful for community-based surveillance of moderate respiratory syncytial virus infection among young infants particularly in resource-limited settings. However, this definition showed modest specificity (29.2%-49.6%), indicating that community-based surveillance may need augmentation with other data.
Highlights
Distribution of infants 12 weeks and younger residing in urban areas of Karachi Pakistan meeting one of three potential
Distribution of infants 12 weeks and younger residing in urban areas of Karachi Pakistan meeting any combination of three potential RSV testing case definitions, and related RSV positivity by case definition
Sensitivity, specificity, and positive and negative predictive values (PPV and NPV, respectively) for three proposed case definitions for RSV testing, with comparison against control infants
Summary
Distribution of infants 12 weeks and younger residing in urban areas of Karachi Pakistan meeting one of three potential RSV testing case definitions, and related RSV positivity by case definition. Case definition symptoms Wheeze or apnea or cyanosis Severe chest indrawing plus (cough or tachypnea)
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