Abstract

Radiological emergencies present unique challenges to the public health care system and carry the potential for major disruptions to clinical care. This review aims to present, first a brief guide of the main clinical and laboratory diagnostic tools for the assessment of the absorbed dose in cases of radiological emergencies and second, the best treatment options for acute whole body and local radiation syndromes. Clinical and laboratory state-of-the-art biodosimetry tools, therapies for acute radiation syndromes according to the severity of the radiation sickness, and isotope-specific preparedness medications as counter-measures for internal contamination are herein proposed as the necessary stockpile of public hospitals against severe radiological accidents.

Highlights

  • The public exposure to ionizing radiation poses a tremendous and complex challenge to the health system [1], due to the degree of hospital preparedness, the availability of special resources and the technical skills from the involved personnel required to confront this kind of emergency [2]

  • Among the requirements to cope with radiation emergencies, public hospitals need high-end diagnostic tools and treatment options

  • Acute radiation sickness (ARSI) is manifested with various clinical syndromes called acute radiation syndromes (ARS); their severity is dose related, as follows [27]: Haemopoietic syndrome, in doses more than 2-6 Gy, gastrointestinal syndrome, in doses more than 6-8 Gy and neurological syndrome, in doses more than 12-15 Gy

Read more

Summary

Introduction

The public exposure to ionizing radiation poses a tremendous and complex challenge to the health system [1], due to the degree of hospital preparedness, the availability of special resources and the technical skills from the involved personnel required to confront this kind of emergency [2]. Among the requirements to cope with radiation emergencies, public hospitals need high-end diagnostic tools and treatment options. Both these items will be described beneath, according to the data of relevant bibliography and the long occupational experience of the authors

Radiation Dose Assessment
Clinical biodosimetry
Laboratory biodosimetry
Treatment requirements Treatment of Acute Radiation Syndromes
Dosimetric considerations
Treatment of high absorbed whole body doses
Internal contamination medications
Prussian blue
Findings
Main preparedness medications list against radiological accidents
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call