Abstract
Scientific endeavor has made it possible to discover and synthesize lipid-lowering drugs but, in most cases, their beneficial effects are overshadowed by their adverse effects. Hence, research interest in the screening of medicinal plants has intensified in recent years with a view of discovering potential antioxidants, lipid, and glucose-lowering phytochemicals. Four-month feeding of carbamazepine (both 5 mg/kg and 20 mg/kg body weight) with a normal diet increased the body mass of rats. Low-density lipoprotein (LDL) cholesterol level was increased based on the oral execution of carbamazepine. But high-density lipoprotein (HDL) cholesterol level and weight of the liver increased slightly and the level of triacylglycerol (TG) and total cholesterol (TC) level remain unchanged. Nonetheless, the Begonia barbata feeding with a normal diet reduced carbamazepine-induced obesity at both high and low doses. The level of LDL cholesterol and liver weight was significantly decreased due to the oral execution of B. barbata together with normal diet and carbamazepine, where HDL level was changed but not significantly.
Highlights
Obesity is most commonly caused by a combination of excessive food intake, lack of physical activity and genetic susceptibility (Yazdi et al, 2015)
Carbamazepine (CRZ) able to increase weight Simultaneously B. barbata leaf extract was given to other two groups of rats which were fed with low dose (ND+CRZLD+BB) and high dose (ND+CRZLD+BB) of carbamazepine daily with normal diet
On the other hand apply the leaf extract of B. barbata is decreasing that weight of rates
Summary
Obesity is most commonly caused by a combination of excessive food intake, lack of physical activity and genetic susceptibility (Yazdi et al, 2015). Obesity progresses towards metabolic syndrome which is defined by a constellation of interconnected physiological, biochemical and clinical factors including dyslipidemia, hypertension, and diabetes, pro inflammatory and pro thrombotic state. These conditions are directly linked to higher level of LDL cholesterol, lower level of HDL cholesterol, oxidative stress and elevated blood glucose. Obesity results from an imbalance of food intake, basal metabolism, and energy expenditure. In most cases, a coalescence of excess energy intake and availability of energy-dense meals is thought to be the main contributor to obesity (Wisse and Kim, 2007)
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