Assessment and comparison of clinico-microbiological efficacy of moxifloxacin plus vancomycin combined therapy with fortified vancomycin in bacterial keratitis

Abstract

To assess and compare clinico-microbiological efficacy of Moxifloxacin (0.5%) plus Vancomycin (2.5%) combined therapy to Fortified Vancomycin (5%) in bacterial keratitis.The present study was conducted on patients who visited eye OPD, J.N.M.C.H and Gandhi Eye Hospital, Aligarh. Patientsiwith bacterial keratitis were diagnosed and included in the study. Right eyes were instilled moxifloxacin plus vancomycin combination therapy and Left eyes were instilled fortified vancomycin. Microbiological results were recorded on first visit and on follow up visits during course of treatment.Total of 32 patients were included in the study. At first visit, only 8 cases were positive for bacterial culture with coagulase negative Staphylococcus (CoNS) being the most common organisms. All the smears became negative in first follow-up (7th day) in both the groups. No significant difference were found in clinical and microbiological study outcome betweenthe two-study groups.We conclude that both the drugs, i.e. moxifloxacin (0.5%) plus vancomycin (2.5%) combined therapy and fortified vancomycin (5%) had good efficiency clinically and in microbial elimination in cases of bacterial keratitis with equivalent outcome.