Abstract
Vitamin D deficiency and high breast density may be associated with increased breast cancer risk. We examined a possible association between vitamin D levels and mammographic breast density in a population of Alaskan women. Patients seen in the Mayo Clinic-Alaska Native Medical Center telemedicine program from December 2014 to December 2017 were enrolled in the study. Pearson correlation was used to estimate the association between mammographic breast density and vitamin D levels. Of the 33 women enrolled, 70% of women self-identified as American Indian/Alaskan Native, 12% as White, 6% as Native Hawaiian/Pacific Islander and 12% as other. Nineteen (58%) participants were taking vitamin D supplementation. No correlation was identified between breast density and serum vitamin D levels overall (correlation= –0.03). Larger studies controlling for vitamin supplementation are needed, as this association could potentially impact breast cancer rates in populations at risk for vitamin D deficiency.
Highlights
IntroductionIn accordance with the ethical standards of the Institutional Review Boards (IRB) and the Helsinki Declaration of 1975, as revised in 2013
Introduction providersThe program served 299 Alaskan women from August 2011 to December 2018.in accordance with the ethical standards of the Institutional Review Boards (IRB) and the Helsinki Declaration of 1975, as revised in 2013
We attempted to determine an association between vitamin D levels and mammographic breast density as a risk factor for breast cancer
Summary
In accordance with the ethical standards of the IRBs and the Helsinki Declaration of 1975, as revised in 2013. Informed consent was obtained from all patients being included in the study. This study was approved by the ANMC suggest that vitamin D may have antiprolif- and the Mayo Clinic Rochester (MCR) erative and anticarcinogenic properties and Institutional Review Boards (IRB), and all in particular, a protective effect against procedures were in accordance with the eth-. Breast cancer.[1] Women with higher levels of ical standards of the IRBs and the Helsinki vitamin D have been reported to have a Declaration of 1975, as revised in 2013. Lower risk of breast cancer.[2] the Patients enrolled in the telemedicine pro-
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