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Abstract
Aim:To evaluate overall survival (OS), glycemic control in cancer patients with and without diabetes mellitus (DM).Patients & methods:Patients (2010–2015) with newly diagnosed prostate, breast, lung, colorectal and pancreatic cancers were identified in institutional cancer registry. Data linked to National Death Index for vital status. 5-year OS estimated; glucose and hemoglobin A1c assessed during year postdiagnosis.Results:We identified 1404 patients (non-DM, n = 936; DM, n = 468). DM cohort had 168 deaths (36%); non-DM, 267 (29%). 5-year OS estimated at 58% (95% CI: 53–64%) for DM and 67% (95% CI: 64–71%) for controls; for matched pairs, hazard ratio: 1.35 (95% CI: 1.02–1.79). Cancer did not harm glycemic control.Conclusion:OS among cancer patients with DM was lower than without DM.
Highlights
diabetes mellitus (DM) was associated with decreased survival across all cancer types
The increased association with comorbidities, rather than only the presence of diabetes mellitus (DM), may be what underlies the greater risk of death observed in the data
Summary
To evaluate overall survival (OS), glycemic control in cancer patients with and without diabetes mellitus (DM). Lay abstract: The aim of this study was to assess how diabetes mellitus (DM) and cancer interact to influence overall survival and glycemic control, through use of a national mortality database, the National Death Index
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