Abstract
BackgroundAn association has been found between the presence of lipid‐specific oligoclonal IgM bands (LS‐OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course.ObjectiveTo investigate lipid‐specific oligoclonal IgM bands as a prognostic biomarker of cognitive impairment in the early stages of multiple sclerosis.MethodsForty‐four patients underwent neuropsychological assessment at baseline and 4 years. Cognitive performance at follow‐up was compared adjusting by age, education, anxiety–depression, and baseline performance.ResultsLS‐OCMB+ patients only performed worse for Long‐Term Storage in the Selective Reminding Test (p = .018).ConclusionThere are no remarkable cognitive differences between LS‐OCMB– and LS‐OCMB+ patients in the early stages of MS.
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