Assessing the Impact of Temperature Management Interventions on Survival Outcomes in Adult Out-of-Hospital Cardiac Arrest: A Comprehensive Review of Randomized Controlled Trials

Abstract

A cardiac arrest patient who has recovered outside the hospital, managing body temperature is beneficial. There is still uncertainty as to what specific circumstances should be met in order for such interventions to be initiated. Researchers have used different methods to study OHCA TTM interventions due to the uncertainty surrounding their outcomes. The study’s main objective is to determine if temperature management affects survival outcomes in adult cardiac arrests occurring outside of the hospital. Several online databases were examined to collect data, including Web of Science, PubMed Central, Medline, Embase and Cochrane. Our study examined several randomized controlled trials, including randomized clinical trials and randomized controlled trials that involved TTM interventions in adult OHCA patients. An analysis was conducted based on the search criteria for screening, collecting, and extracting data. Based primarily on qualitative analysis, a synthesis was conducted. There were 21 studies with a total of 11435 participants, with a median sample of 355, and none of them demonstrated sufficient qualitative and quantitative evidence indicating that TTM interventional variants were safe, feasible, efficient, and effective on neurological and mortality outcomes in OHCA patients.