Abstract
In the present study, sustained release tablet of metformin hydrochloride were formulated and analyse the impact of material and process attributes on dissolution profile employing Quality by design (QbD) approach. Taguchi design was employed to screen the critical factors and amount of HPMC, amount of compritol and compression force was selected as critical factors. The effect of critical factors on the critical quality attributes (CQAs) of sustained, such as cumulative drug release at 2 hr (CDR 2), at 5 hr (CDR 5) and 8 hr (CDR8) was evaluated using Box-Behnken design. The optimised formulation was achieved with set of variable, such as a amount of HPMC (24.9%), amount of compritol (6.93%) and compression force (7.09 KN) and resulted into a tablet with a cumulative drug release 18.53%, 47.10% and 85% at 2, 5 and 8 hr respectively which was close to predicted value.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.