Assessing the Health Loss from Kashin-Beck Disease and Its Relationship with Environmental Selenium in Qamdo District of Tibet, China.

Jing Wang,Cangjue Nima,Linsheng Yang,Hairong Li,Shengcheng Zhao,Hongqiang Gong

doi:10.3390/ijerph18010011

Abstract

Kashin-Beck Disease (KBD) is one of major endemic diseases in China. In this study, we estimated the health loss from KBD in Qamdo district of Tibet using the years lived with disability (YLD) metric and investigated the influence of environmental selenium (Se) on it by multiple regression model. The results showed that YLD rates produced a different ranking of health loss of KBD from that produced by prevalence rates between Basu and Luolong County, with higher health loss from KBD (43.61 YLD/1000) but lower prevalence (17.86%) in Basu County. YLD rates in two counites were both highest for the 45–64 years age group. Compared with the prevalence rate, the YLD rate had a closer relation to environmental Se and was significantly negatively correlated with Se in both soil and highland barley. The multiple linear regression further revealed that Se contents in cultivated soil and highland barley were main influencing factors for the health loss of KBD, which could explain 90.5% of the variation in YLD rates. The information obtained highlights the significance of the YLD metric in exploring the environmental etiology of KBD and provides important information on which to base decisions on future prevention and control of endemic diseases.

Highlights

Kashin-Beck disease (KBD) is a chronic, multisite, deformative osteoarthropathy, which is characterized by necrosis and remodeling of cartilage including growth plates [1,2].It mainly harms the growth and development of children and adolescents, involving multiple symptoms, such as the short fingers and limbs, the retarded growth, and disabilities in the advanced stages [3,4]
KBD of grade III (654.69 years lived with disability (YLD), 37.0% of total YLDs) contributed most to the total YLDs in Basu; while in Luolong, 77.4% of total YLDs were due to KBD of grades were assigned as 0.117 (grade I) (1282.69 YLDs)
It was found that 34.4% and 7.9% of patients were diagnosed as KBD of grade II and III in Basu and Luolong County, respectively, indicating that the health loss due to KBD of grade II and III in Basu are relatively high

Summary

Introduction

Kashin-Beck disease (KBD) is a chronic, multisite, deformative osteoarthropathy, which is characterized by necrosis and remodeling of cartilage including growth plates [1,2] It mainly harms the growth and development of children and adolescents, involving multiple symptoms, such as the short fingers and limbs, the retarded growth, and disabilities in the advanced stages [3,4]. KBD is distributed diagonally from northeastern China to Tibet in the southwest, with additional endemic regions in neighboring areas of Russia and some regions of Vietnam and Korea [1,4] It is still relatively active in Tibet since new clinical cases were detected occasionally in some affected counties [5]. This disease has been one of the major endemic diseases that severely impact the physical health and life quality of local residents and hinder the economic and social development of disease areas

Methods

Results

Discussion

Conclusion