Year-end Sale % OFF 
Abstract
Kainate (KA) is a potent neuroexcitatory agent that induces seizure and brain damage syndromes with increasing efficiency during maturation. It has been suggested that the selective neuronal damage induced by KA may result not only from its depolarizing actions, but also from intracellular accumulation of Ca2+. The effects of KA are mediated by specific high-affinity receptors, enriched in the hippocampus. Members of this class of receptors, GluR5 and GluR6, have been characterized by cDNA cloning. Ca2+ permeability of the GluR6 receptor is determined by editing in the corresponding RNA. We report here a rapid PCR-based approach to assess in all experimental conditions the levels of GluR5 and GluR6 editing in the transmembrane TMII region. We show that editing in both GluR5 and GluR6 RNA is developmentally regulated and that different regions of the adult rat hippocampus demonstrate distinct levels of GluR6 editing.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
