Abstract
ObjectiveTo evaluate whether patients with COVID-19 who have tested re-positive with the PCR test for the SARS-CoV-2 virus are infectious is a challenge in the current circumstances. A follow-up survey was conducted with healthcare personnel (HCP) who were exposed to a patient whose PCR test results for SARS-CoV-2 were re-positive 18 days after the initial confirmation of negative PCR results.ResultsWe studied a total of 15 HCP who had contact exposures (15/15) and aerosol exposures (7/15). None of them tested positive for IgG against SARS-CoV-2 on blood examination. None of them had any symptoms during 10 days of active isolation. All PCR tests conducted using the nasopharyngeal swabs collected from the HCP on day 10 were negative. No apparent infection was found in any of the HCP who had contact exposure with and/or aerosol exposure to the patient whose PCR test results for SARS-CoV-2 were re-positive 18 days after the initial confirmation of negative results of PCR tests for SARS-CoV-2.Clinical trial: Trial Registration: No. 170, approved June 10th, 2020 by the ethics committee of Sakai City Medical Center.
Highlights
The spread of COVID-19 is still on-going in various regions
Material and Methods We identified the healthcare personnel (HCP) who needed isolation in our hospital according to the Centers for Disease Control and Prevention (CDC) guidelines for asymptomatic HCP who are exposed to individuals with confirmed COVID-19 [2]
She was diagnosed with COVID-19 using the Polymerase chain reaction (PCR) test for SARS-CoV-2 before admission
Summary
The index patient first developed COVID-19 symptoms 10 days before she was admitted to our hospital She was diagnosed with COVID-19 using the PCR test for SARS-CoV-2 before admission. 26, 29, and 33 days after the first symptoms appeared, nucleic acid amplification tests for the specimen from the lower respiratory tract of SARS-CoV-2 were performed; the results of all tests were negative. We did not perform PCR tests for SARS-CoV-2 until the 63rd day of illness, and the result of this test was re-negative. All PCR tests performed using a nasopharyngeal swab obtained on the 10th day after the exposure were negative, and the results of the tests for IgG antibodies to SARS-CoV-2 on the specimens collected approximately 20 days after exposure were negative
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