Abstract
Purpose: The worldwide prevalence of metabolic disorders such as diabetes is increasing rapidly. Currently, the complications of diabetes are the major health concern. The aim of this study was to investigate the effect of high performance (HP) inulin supplementation on glucose homeostasis via KLF5 mRNA expression in adults with type 2 diabetes.Methods: In the present clinical trial conducted for a duration of 6 weeks, 46 volunteers diabetic patients referring to diabetes clinic in Tabriz, Iran, were randomly assigned into intervention (n= 23, consuming 10 gr/d HP inulin) and control groups (n= 23, consuming 10 gr/ d starch). We assessed glycemic and anthropometric indices, blood lipids and plasmatic level of miR-375 as well as KLF5 mRNA expression before and after the intervention.Results: Findings indicated that inulin supplementation significantly decreased fasting plasma glucose (FPG) in comparison to the placebo group (P<0.001). Also Intra-group and between group results showed that inulin supplementation resulted in significant decrease in KLF5 mRNA expression in peripheral blood mononuclear cells (PBMCs) (Fold change: 0.61± 0.11; P-value= 0.001) and significant increase in plasmatic level of miR-375 (Fold change: 3.75± 0.70; P-value=0.004).Conclusion: Considering the improvements of FPG level in diabetic patients, it seems that HP inulin supplementation may be beneficial in controlling diabetes via the expression of some genes. However, further studies are needed to achieve concise conclusions.
Highlights
Diabetes mellitus (DM) as a complex metabolic disorder influenced by various environmental and genetic factors has become a common health problem in the entire world.[1]
Intra-group and between-group statistical analysis revealed that Inulin supplementation resulted in significant decrease in kruppel like factor 5 (KLF5) messenger RNA (mRNA) expression of KLF5 (Fold change: 0.61± 0.11; P-value= 0.001) (Figure 2)
The findings of the present study indicated that high performance (HP) inulin supplementation decreased fasting plasma glucose (FPG) and KLF5 mRNA expression significantly
Summary
Diabetes mellitus (DM) as a complex metabolic disorder influenced by various environmental and genetic factors has become a common health problem in the entire world.[1] According to recent reports it is estimated that by the year 2030, at least 366 million people will suffer from diabetes.[2] Recent scientific advances point to manipulation of gut microbiota as contributing factors for preventing or controlling diabetes.[2,3] The intestinal microbiota is a vital organ with trillions of commensally microorganisms which is involved in host metabolism. Dietary components, prebiotics are considered as functional foods that provide beneficial health effects on the intestinal tract. Prebiotics are defined as “ non-viable food components that confer health benefits on the host in association with modulation of the microbiota”.4
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