Assessing the contribution of nine preventable risk factors attributed to the burden of early onset colorectal cancer in Gulf Cooperation Council (GCC) countries

Abstract

Alarming trends in the incidence and prevalence of early onset colorectal cancer (EO-CRC) have been noted, with the highest increases in regions with a high-middle Socio-demographic Index (SDI), including the Gulf Cooperation Council (GCC) nations. This study aims to assess the contribution of nine preventable risk factors attributed to the burden of early onset colorectal cancer in GCC countries. The Global Burden of Disease (GBD) 2019 was the source of our data. This database offers comprehensive and accessible epidemiological information on 369 diseases and injuries, along with 87 risk factors, from 1990 to 2019. Nine EO-CRC risk factors were included in the study. In 2019, the highest attributable proportions of risk factors for male EO-CRC werehigh-body mass index ranging from (20.43% to 26.21%). The second highest attributable proportions of risk factors for EO-CRC in male was the diet low in milk, and the first highest attributable proportions of risk factors for EO-CRC for female was the diet low in milk. The attributable proportions of physical inactivity risk factor were consistently higher among female in Saudi Arabia, Kuwait, and Qatar, while it was slightly lower among higher among male in United Arab Emirates, Oman, and Bahrain. This study highlights the significant role of high-body mass index and low milk consumption as major preventable risk factors for early onset colorectal cancer in GCC countries. Promoting healthier lifestyles and physical activity can help control BMI levels and reduce the incidence of EO-CRC.