Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients

Samar Samir Abdelmajed,Mohamed A El-Dessouky,Doaa S Salaheldin,Naglaa Abu-Mandil Hassan,Moushira Erfan Zaki,Somaia Ismail

doi:10.1186/s43141-021-00214-2

Abstract

BackgroundVariants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident of multiple autoimmune diseases including type 1 diabetes mellitus (T1D). It is a genetically related auto-immune disorder that resulted from T cell-mediated destruction of pancreatic cells that are in control for the production of insulin in the blood. The current study aimed to clarify the role of STAT4 (rs7574865) variant allelic and genotypic variations in the susceptibility to type 1 diabetes among Egyptians by using the real-time PCR. ResultsA total of 100 patients and 100 controls were genotyped for rs7574865, and the biochemical and anthropometric parameters were measured to show that type 1 diabetic patients had significantly higher levels of HbA1c and triglycerides compared to non-diabetic individuals (P < 0.05). And genetically, the T allele and GT genotype have a significant correlation with diabetes type 1. ConclusionIt was confirmed by this study that the rs7574865 T allele and GT genotype have a significant correlation with diabetes type 1 incidence among Egyptian patients.

Highlights

Variants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident of multiple autoimmune diseases including type 1 diabetes mellitus (T1D)
STAT4 gene is vital in the development of Th1 cells so it plays an important role in immunity, and that is why it was associated with different immune diseases
STAT4 genotype frequencies were investigated in all 200 subjects (100 type 1 diabetes patients and 100 controls) as presented in (Table 1)

Summary

Introduction

Variants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident of multiple autoimmune diseases including type 1 diabetes mellitus (T1D). It is a genetically related auto-immune disorder that resulted from T cell-mediated destruction of pancreatic cells that are in control for the production of insulin in the blood. Signal transducers and activators of transcription (STAT) proteins are activated by many cytokines, the mechanism of STAT4-mediated IL-12 signaling [9,10,11], and there is a strong evidence that supports a role of IL-12 in autoimmune diabetes [12,13,14]. This study, inspects the impact of STAT4 variants on the vulnerability of type 1 diabetes among Egyptians

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Discussion

Conclusion