Abstract
BackgroundPremature delivery is among the leading causes of perinatal mortality and morbidity in developed societies, which is an important obstetrics problem. Maternal periodontitis is a prevalent condition that has been suspected to be associated with adverse pregnancy outcomes such as premature birth. However, there are still conflicting results about this possible relationship, therefore this study was designed to test the association between maternal periodontitis and premature birth. This study also provides information about a new screening tool recommended for use by nurses and midwives to screen for periodontal diseases during antenatal consultations in order to improve the health of mothers and children.MethodsA retrospective case-control study was conducted at 12 health facilities in the Southern Province of Rwanda from February to August, 2018. A total of 555 women in the postpartum period were enrolled in the study. Cases and controls were enrolled in a ratio of 1:2; each enrolled case of preterm birth was followed by 2 unmatched control subjects that were next on the register and who delivered at term gestation. A total of 185 cases of preterm deliveries and 370 controls of term delivery were enrolled in the study. Multivariate regression analysis was used and the independent variables were hierarchically entered in three groups: The first group involved demographic variables that were put in the regression model as Step 1. The second group was made up of other potential risk factors that were placed in the regression model as the second step. Periodontitis was entered in the final regression step, as it was hypothesized as the main predictor variable.ResultsA statistically significant association was found between periodontitis and premature birth. Women who had periodontitis had 6 times the odds of giving birth to premature birth infants compared to women who had no periodontitis (OR: 6.360, 95% CI 3.9, 10.4).ConclusionThe study results indicate that periodontitis is strongly associated with premature birth. Preventive solutions including the use of a periodontitis screening tool for nurses and midwives during antenatal care consultations, are highly recommended.
Highlights
Premature delivery is among the leading causes of perinatal mortality and morbidity in developed societies, which is an important obstetrics problem
Cases and controls were enrolled in a ratio of 1:2 and each enrolled case of premature birth was followed by 2 control subjects who delivered at term gestation that were on the register
When these demographic variables were associated with premature birth, only employment status was statistically associated with premature birth (p = 0.054)
Summary
Premature delivery is among the leading causes of perinatal mortality and morbidity in developed societies, which is an important obstetrics problem. Premature births are among the leading causes of perinatal mortality and morbidity globally [1]. In the United States, premature births and associated complications, such as immature lung development, reduced feeding ability and inferior weight gain, result in longer hospital stays and a higher cost of health care, and are responsible for up 70% of prenatal and infant mortality. Premature birth is the leading cause of neonatal mortality in low-income countries [4]. According to a demographic health survey in Rwanda (DHS, 2014–2015), the incidence of low birth weight deliveries was 6.3% [5], and according to the Rwanda Population Reference Bureau, premature birth complications are among the top ten causes of child mortality in Rwanda [6]
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