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Abstract
To the Editor: We agree with Grant et al.1 that it is important to establish the relation between the extent of chemotherapy response and time to tumor progression or survival in patients with malignant glioma. In light of the emerging chemotherapy agents with cytostatic and anti-angiogenic properties, this article is both timely and important to the design of future clinical trials. Although the statistical method used in the analysis is well entrenched in neuro-oncology literature, we offer our opinion on this matter because this is a mistake commonly made by investigators in this field. Because …
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