ASSESSING RACIAL DIFFERENCE IN PULMONARY PRESSURES IN CARDIAC SARCOIDOSIS

Abstract

SESSION TITLE: Cardiovascular Disease SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: The manifestations of sarcoidosis can vary significantly by race. It has been shown that non-white patients with pulmonary sarcoidosis are more likely to have and pulmonary hypertension. However, the explanation for racial differences in sarcoidosis remain poorly understood. This study aims to evaluate racial differences in pulmonary pressure in cardiac sarcoidosis (CS) patients. METHODS: We leveraged a large, racially diverse, multicenter registry of CS patients. Patients were included in the registry if they had clinical suspicion of CS and corroborating endocardial biopsy, PET scan, or cardiac MRI findings. Echocardiography and right heart catheterizations (RHC) results were analyzed and compared by race. RESULTS: A total of 50 patients with echocardiographic and RHC data were identified, 48% (n=24) were non-white, and mean age was 55±10 for white patients and 57±10 for non-white patients (p=0.40). Baseline comorbidities, including OSA, BMI, CAD, and LV systolic dysfunction were similar between groups. Systolic function was not different in whites vs. non-white patients with CS (46 vs. 41, p=0.32). White CS patients had a similar proportion of pulmonary sarcoidosis as non-white patients (65% vs. 68%, p=0.83). Right ventricular systolic pressure (RVSP) by echocardiography, RVSP by RHC, pulmonary vascular resistance, and mean pulmonary artery pressure were similar in whites vs. non-whites (37 vs. 39, p-0.77; 15.4 vs. 10.6, p=0.15; 2.09 vs. 2.84, p=0.48; 29.5 vs. 30.3, p=0.92, respectively). CONCLUSIONS: In a multicenter registry of CS patients, right heart pressures by echocardiogram and RHC were no different in white versus non-white patients. The development of elevated pulmonary pressures in CS patients may be multifactorial, driven by factors other than race. CLINICAL IMPLICATIONS: Although non-white patients with pulmonary sarcoidosis have been shown to have a higher incidence of elevated pulmonary pressures, there is no racial difference in pulmonary pressures among CS patients. DISCLOSURES: No relevant relationships by Anuj Basil, source=Web Response No relevant relationships by Matthew Bocchese, source=Web Response No relevant relationships by Crystal Chen, source=Web Response Consultant relationship with Abbott Laboratories Please note: $5001 - $20000 Added 04/11/2020 by Joshua Cooper, source=Web Response, value=Consulting fee Advisory Committee Member relationship with Abbott Medical Please note: $5001 - $20000 Added 04/11/2020 by Joshua Cooper, source=Web Response, value=Consulting fee Consultant relationship with Johnson & Johnson Please note: $20001 - $100000 Added 04/11/2020 by Joshua Cooper, source=Web Response, value=Consulting fee Consultant relationship with Boston Scientific Please note: $5001 - $20000 Added 04/11/2020 by Joshua Cooper, source=Web Response, value=Consulting fee Consultant relationship with Biosense Webster Please note: $5001 - $20000 Added 04/11/2020 by Joshua Cooper, source=Web Response, value=Consulting fee Consultant relationship with Medtronic Inc Please note: $1001 - $5000 Added 04/11/2020 by Joshua Cooper, source=Web Response, value=Consulting fee No relevant relationships by Edmond Cronin, source=Web Response No relevant relationships by chethan gangireddy, source=Web Response No relevant relationships by Rohit Gupta, source=Web Response No relevant relationships by Abdullah Haddad, source=Web Response No relevant relationships by Benjamin Rosenfeld, source=Web Response No relevant relationships by David Rosenthal, source=Web Response no disclosure on file for Vasanth Vedantham; No relevant relationships by Isaac Whitman, source=Web Response