Abstract
Pore formation affects the structural integrity of the lipid membrane, compromising its ability to act as a semi-permeable barrier and eventually leading to cell death. We present results obtained via atomic force microscopy (AFM) when lipid bilayer patches made dimyristoylphosphatidylcholine (DMPC) with increasing cholesterol content were subjected to the action of an cationic antimicrobial peptide (AMP), Protegrin-1 (PG-1). The cholesterol content was varied from 0% to 30%, where the lower and the upper bounds represent the cholesterol content in bacterial and mammalian cells, respectively. In the absence of cholesterol, PG-1 penetrated into the bilayer, leading to pore formation.
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