Abstract
Angiogenesis, the formation of new blood vessels, is essential for tumor growth. Inhibition of angiogenesis represents a novel strategy for the treatment of cancer (1). Vascular Endothelial Growth Factor (VEGFs) is a key angiogenic factor which stimulates endothelial cell proliferation and migration. VEGF may also contribute to disease progression through a profound permeabilizing effect on tumor vasculature. As such, inhibition of VEGF signal-transduction represents a good target for therapeutic intervention. The purpose of this study was to quantify perfusion and capillary permeability changes induced by the VEGF receptor tyrosine kinase inhibitor, ZD4190, using a macromolecular MRI contrast media, P 792.
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