Abstract
Radiation toxicity is a major obstacle to effective head and neck (HN) cancer treatment. Treatment-related toxicity to lymphatic tissues in the HN region could significantly diminish patient's quality-of-life, with lymphedema resulting in more than half of HN cancer patients who undergo surgery and radiation therapy. Impairment of lymphatics due to radiation therapy may be expected because radiation exposures could cause loss of capillary lymphatics and tissue fibrosis. In a pilot study, we sought to visualize lymphatic contractile function and architecture before and after cancer treatments using near-infrared fluorescence (NIRF) lymphatic imaging.
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