Abstract
30 The aims of the study were to determine 1.) whether the waist circumference (WC) or the waist-to-hip ratio (WHR) is better correlated with insulin resistant coronary artery disease (CAD) risk factors, and 2.) whether the associations between fasting insulin and selected CAD risk factor components of the insulin resistant metabolic syndrome (i.e., high density lipoprotein cholesterol (HDL-C), triglycerides (TG), systolic (SBP), and diastolic (DBP) blood pressures) are more dependent upon a common association with either WC or WHR. The sample included 134 postmenopausal women with no history of cardiovascular disease or diabetes mellitus, aged 50-78 years, and with body mass index values ranging from 18-46 kg/m2. The WC and WHR were similarly correlated with HDL-C (r=−.369, p<.001; r=−.392, p<.001), TG (r=.432, p<.001; r=.452, p<.001), and DBP (r=.234, p=.006; r=.156, p=.071, NS), respectively. There were no significant correlations of SBP with either WC (r=.098. p=.258) or with WHR (r=.144, p=.097). However, fasting insulin was more highly correlated with WC (r=.728, p<.001) than with WHR (r=.532, P<.001). The associations between fasting insulin and the other CAD risk factors were analyzed before adjusting for WC and WHR by simple correlation and after adjusting for WC and WHR by multiple regression (table).TableThe significant correlations of fasting insulin with HDL-C, TG, and DBP became nonsignificant (p≥0.06) after adjusting for WC. By contrast, correlations of fasting insulin with HDL-C and with DBP remained significant after adjusting for WHR. We conclude that WC and WHR are similarly correlated with lipid and blood pressure levels. However, because WC is more highly correlated with fasting insulin and because WC explains more of the common association between fasting insulin and the other CAD risk factors, WC may be a better anthropometric index than WHR for assessing insulin resistant CAD risk in postmenopausal women. Supported by grants from the OSU research council the Erkkila Foundation
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