Abstract
BackgroundCognitive impairment (CI) is one of the most prevalent symptoms of multiple sclerosis (MS). However, it is difficult to include cognitive assessment as part of MS standard care since the comprehensive neuropsychological examinations are usually time-consuming and extensive.ObjectiveTo improve access to CI assessment, we evaluated the feasibility and potential assessment sensitivity of a tablet-based cognitive battery in patients with MS.MethodsIn total, 53 participants with MS (24 [45%] with CI and 29 [55%] without CI) and 24 non-MS participants were assessed with a tablet-based cognitive battery (Adaptive Cognitive Evaluation [ACE]) and standard cognitive measures, including the Symbol Digit Modalities Test (SDMT) and the Paced Auditory Serial Addition Test (PASAT). Associations between performance in ACE and the SDMT/PASAT were explored, with group comparisons to evaluate whether ACE modules can capture group-level differences.ResultsCorrelations between performance in ACE and the SDMT (R=–0.57, P<.001), as well as PASAT (R=–0.39, P=.01), were observed. Compared to non-MS and non-CI MS groups, the CI MS group showed a slower reaction time (CI MS vs non-MS: P<.001; CI MS vs non-CI MS: P=.004) and a higher attention cost (CI MS vs non-MS: P=.02; CI MS vs non-CI MS: P<.001).ConclusionsThese results provide preliminary evidence that ACE, a tablet-based cognitive assessment battery, provides modules that could potentially serve as a digital cognitive assessment for people with MS.Trial RegistrationClinicalTrials.gov NCT03569618; https://clinicaltrials.gov/ct2/show/NCT03569618
Highlights
BackgroundMultiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disorder, and it is the leading cause of major disability in young adults
The 53 participants with multiple sclerosis (MS) were divided into Cognitive impairment (CI) (n=24 [45%]) and non-CI (n=29 [55%]) subgroups based on to their baseline Symbol Digit Modalities Test (SDMT) z score
The results suggest that the Adaptive Cognitive Evaluation BRT (ACE) Boxed module can identify group-level differences between CI participants with MS, non-CI participants with MS, and non-MS participants
Summary
BackgroundMultiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disorder, and it is the leading cause of major disability in young adults. To date, cognitive assessment in MS relies on a comprehensive neuropsychological examination, which is time-consuming and extensive; it makes it difficult to include cognitive assessment/monitoring as part of MS standard care. It is difficult to include cognitive assessment as part of MS standard care since the comprehensive neuropsychological examinations are usually time-consuming and extensive. Objective: To improve access to CI assessment, we evaluated the feasibility and potential assessment sensitivity of a tablet-based cognitive battery in patients with MS. Methods: In total, 53 participants with MS (24 [45%] with CI and 29 [55%] without CI) and 24 non-MS participants were assessed with a tablet-based cognitive battery (Adaptive Cognitive Evaluation [ACE]) and standard cognitive measures, including the Symbol Digit Modalities Test (SDMT) and the Paced Auditory Serial Addition Test (PASAT).
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