Abstract
Cell adhesion is essential in cell communication, cell regulation, and the development and maintenance of tissues. The mechanical interactions between a cell and its extracellular matrix (ECM) can influence and control the function and the behavior of cells. Gaining a better understanding about the mechanical interaction of cell adhesion can provide advances in biomaterial for implants, potential drug treatments for improvement of cell adhesion of implants, and fundamental understanding of signaling pathways related to cell adhesion. We have developed a non-invasive real time method using the quartz crystal microbalance with dissipation monitoring (QCM-D) to quantitatively monitor such cellular processes using the dissipation factor ΔD. In this study, we have used this method to examine the adhesion of human epidermal keratinocytes to the QCM-D sensor surface coated with titanium, a common material for medical implant. The key results from this study have validated this method as an in-vitro approach for examining cell-implant interaction.
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