Abstract

An unmet need exists in high-speed and highly-sensitive intraoperative assessment of breast cancer margin during conservation surgical procedures. Here, we demonstrate a multispectral photoacoustic tomography system for breast tumor margin assessment using fat and hemoglobin as contrasts. This system provides ~3 mm tissue depth and ~125 μm axial resolution. The results agreed with the histological findings. A high sensitivity in margin assessment was accomplished, which opens a compelling way to intraoperative margin assessment.

Highlights

  • Breast-conserving surgery, or lumpectomy, is well accepted for breast cancer treatment [1,2,3,4]

  • We demonstrate a multispectral Photoacoustic tomography (PAT) system for breast cancer margin detection through multi-spectral excitation between 1100 nm and 1250 nm, where both hemoglobin and fat can be visualized

  • The contrast was too vague to distinguish the tumor versus the normal tissue

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Summary

Introduction

Breast-conserving surgery, or lumpectomy, is well accepted for breast cancer treatment [1,2,3,4]. To prevent local cancer recurrence after lumpectomy, histology is performed to check whether the excised tumor specimen is surrounded by a sufficient amount of normal tissue [5,6,7,8]. #233221 - $15.00 USD Received 26 Jan 2015; revised 3 Mar 2015; accepted 5 Mar 2015; published 12 Mar 2015 the tumor, is identified, a second operation will be performed to minimize the chance of cancer recurrence [5, 9,10,11,12,13]. The re-operation rate ranges from 20 to 70 percent [12,13,14,15,16,17] Such high re-operation rate highlights a critical need for rapid and highly sensitive intraoperative margin assessment.

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