Abstract
An unmet need exists in high-speed and highly-sensitive intraoperative assessment of breast cancer margin during conservation surgical procedures. Here, we demonstrate a multispectral photoacoustic tomography system for breast tumor margin assessment using fat and hemoglobin as contrasts. This system provides ~3 mm tissue depth and ~125 μm axial resolution. The results agreed with the histological findings. A high sensitivity in margin assessment was accomplished, which opens a compelling way to intraoperative margin assessment.
Highlights
Breast-conserving surgery, or lumpectomy, is well accepted for breast cancer treatment [1,2,3,4]
We demonstrate a multispectral Photoacoustic tomography (PAT) system for breast cancer margin detection through multi-spectral excitation between 1100 nm and 1250 nm, where both hemoglobin and fat can be visualized
The contrast was too vague to distinguish the tumor versus the normal tissue
Summary
Breast-conserving surgery, or lumpectomy, is well accepted for breast cancer treatment [1,2,3,4]. To prevent local cancer recurrence after lumpectomy, histology is performed to check whether the excised tumor specimen is surrounded by a sufficient amount of normal tissue [5,6,7,8]. #233221 - $15.00 USD Received 26 Jan 2015; revised 3 Mar 2015; accepted 5 Mar 2015; published 12 Mar 2015 the tumor, is identified, a second operation will be performed to minimize the chance of cancer recurrence [5, 9,10,11,12,13]. The re-operation rate ranges from 20 to 70 percent [12,13,14,15,16,17] Such high re-operation rate highlights a critical need for rapid and highly sensitive intraoperative margin assessment.
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