Abstract
Context: Blood platelets may offer as RNA biomarker source for cancer as recently described for an oncogenic transcript in glioma patients and for PCA3 in prostate cancer (PCa) patients.Objective: Here, we elaborated on this aspect for PCa.Materials and methods: PCA3 and other PCa-associated RNA markers were measured in platelets of PCa patients (cases) and healthy subjects (controls) in comparison to PCa cell lines by relative quantitative RT-PCR.Results: The RNA markers displayed heterogeneous expression patterns in cell lines and platelets, however, without significant differences between cases and controls.Discussion and conclusion: The data do not support platelets as a profitable RNA source for early detection of PCa. Nonetheless, certain PCa-derived RNA markers in platelets may merit further investigation as potential prognostic biomarkers for PCa.
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