Abstract
"Assessing Adherent Cell Mechanical Behavior by 6 and 12-Strut Tensegrity Model"
Highlights
Most functions of living cells, including cell growth and differentiation, are related to cell shape deformation
Number of structures have been proposed to investigate the behavior of the cytoskeleton which most of them were based on stretch elements which only stand against tension forces. actin filaments are rope-shaped filaments that only tolerate tensile forces
We suggested two different tensegrity structures to examine the effect of the complexities of these structures in response to mechanical stimulus
Summary
Most functions of living cells, including cell growth and differentiation, are related to cell shape deformation. In addition to its effect on cell shape, structure and deformation, the cytoskeleton is the main factor of transferring mechanical forces through the cell [2,3]. The cytoskeleton is composed of three main strands of the actin, microtubule and intermediate filaments. Many experiments have proved that actin and intermediate filaments are under tensile forces, while microtubules are suitable to withstand compressive forces [4,5]. To assess the overall behavior of the cytoskeleton, several computational models like pre-tensioned cable network [6] and semi-flexible network [7] have been presented. Most of these models focus only on the tensile elements. One of the computational models is a tensegrity model in which both of the compressive elements and tensile elements are involved
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