Assessement of left ventricular diastolic function in patients with early type 2 diabetes mellitus by wave intensity

Abstract

Objective To assess the left ventricular diastolic function in patients with early type 2 diabetes mellitus(T2DM) and combined with hypertension by using wave intensity(WI) and Doppler tissue imaging(DTI).Methods 21 patients with T2DM and 25 T2DM patients with essential hypertension group (T2DM + EH),all of which had left ventricular ejection fraction (LVEF) more than 50％,were enrolled in this study,and 25 healthy volunteers were taken as control group.Each patient underwent conventional echocardiography,DTI and WI exam.Peak velocities of early (E) and late (A) mitral inflow,peak early (Ea) and late (Aa) diastolic velocities of mitral annulus,E/Ea,and deceleration wave intensity (W2) of right common carotid artery(CCA) in three groups were measured and compared.Results Compared with the control group,W2 in T2DM group increased significantly (P ＜0.01),Ea was reduced (P ＜0.05),and E/Ea was significantly increased (P ＜0.01),Ea was significantly reduced (P ＜0.01) and W2 increased significantly(P ＜0.05) in T2DM + EH group.Compared with the T2DM group,E/Ea in T2DM + EH group was increased (P ＜0.05),while W2 and Ea in T2DM + EH group reduced,but no statistically significant differences were found.Conclusions WI combined with DTI may offer a new rapid method in noninvasive and comprehensive evaluation of left ventricular diastolic dysfunction in patients with T2DM and T2DM combined with EH. Key words: Echocardiography; Diabetes mellitus, type 2 ; Hypertension; Ventricular function, left