Abstract

A biosensor is an analytical instrument that combines a biological component with a physicochemical detector to detect a chemical molecule. A biosensor is a biological detection device that combines a biological component with a transducer to perform biochemical amount measurement. Biosensors are often designed to convert physical, chemical, or biological events into measurable signals, providing qualitative and/or quantitative data on the target analytes. While the topic of biosensors has attracted a lot of attention from scientists, combining it with micro fluidics could result in even more substantial gains in terms of sensitivity and specificity, resolution, automation, throughput, repeatability, dependability, and accuracy. Biosensors-on-chip (BoC) might thus serve as a bridge between diagnostics in central laboratories and diagnostics at the patient's bedside, allowing for significant breakthroughs in point-of-care (PoC) diagnostic applications. The purpose of this publication is to present an up-to-date review of BoC system development and their most current application in cancer, infectious diseases, and neurological disorders diagnosis. Leland C. Clark invented enzyme electrodes in 1962, which marked the beginning of biosensor development. A biosensor typically consists of an enzyme, antibody, or cell receptor, as well as a detecting device or transducer. Covalent bonding, matrix entrapment, physical adsorption, and membrane entrapment are some of the ways used to combine these two elements. A biosensor is a type of analytical equipment that detects chemical substances. They normally consist of three segments: sensor, transducer, and related electrons, and combine a biological component with a physicochemical conductor. Keywords: Biosensor chips, Silicon square chips, integrated photonic biosensors, revolutionize biology, bioreceptor, Biosensor technology

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