Assesment Of Hpv Dna Positive İndividuals İn Sivas Province İn Terms Of Some Variables

Abstract

Background: Cervical cancer is one of the most common cancers in women and causes death. Revealing the distribution of HPV prevalence and types in cervical cancer remains important for both treatment and vaccination strategies. The goal of this study is to determine the HPV DNA subtypes of women who are positive for Human Papilloma Virus (HPV) screening, and to evaluate their sociodemographic characteristics and cervical smear results. 
 Methods: The study was conducted on 215 women who were directed to Sivas Cumhuriyet University Obstetry and Gynocology outpatient clinic by her gynocologists or family physicians between 2015-2018 years. A questionnary containing datas of patients about age, education levels and jobs of both spouses, smoking status, obstetric history and age of first sexual intercourse was filled out by the researcher. The data were analysed with SPSS (vers 23.0) program and significance level was taken as 0.05.
 Results: The most prevalent HPV types were type 16 and category of the others; with the rates of respectively 47% (n: 101), 40% (n: 86). The frequencies of ASCUS (undetermined atypical squamous epithelial cells), LGSIL (low-grade squamous intraepithelial lesion) and HGSIL (high-grade squamous intraepithelial lesion) were respectively found to be 7.9% (n: 17), 23.7% (n: 51) and 1.9% (n: 4). The relationship between HPV types and Pap Smear results was statistically significant (p: 0.011). There was no difference between patients and their spouses about education levels and occupations; and among patients on smoking status, menstrual patterns, age at first sexual intercourse and family planning methods and HPV types (p> 0.05). In women above aged 55, only two types of HPV DNA were observed; which were type 16 and category of the others (p: 0.005). The relationship between abortion history and HPV types was found out to be significant (p: 0.016). 
 Conclusion: This study has contributed to the literature by revealing the types of HPV which observed in Sivas province over a period of 3 years.