Abstract
Multiple formulations of iron oxide nanoparticles (IONPs) have been proposed for enhancing contrast in magnetic resonance imaging (MRI) and for increasing efficacy in thermal ablation therapies. However, insufficient accumulation at the disease site and low magnetic performance hamper the clinical application of IONPs. Here, 20 nm iron oxide nanocubes were assembled into larger nanoconstructs externally stabilized by a serum albumin coating. The resulting assemblies of nanocubes (ANCs) had an average diameter of 100 nm and exhibited transverse relaxivity (r2 = 678.9 ± 29.0 mM‒1·s‒1 at 1.41 T) and heating efficiency (specific absorption rate of 109.8 ± 12.8 W·g‒1 at 512 kHz and 10 kA·m‒1). In mice bearing glioblastoma multiforme tumors, Cy5.5-labeled ANCs allowed visualization of malignant masses via both near infrared fluorescent and magnetic resonance imaging. Also, upon systemic administration of ANCs (5 mgFe·kg‒1), 30 min of daily exposure to alternating magnetic fields for three consecutive days was sufficient to halt tumor progression. This study demonstrates that intravascular administration of ANCs can effectively visualize and treat neoplastic masses.
Highlights
Iron oxide nanoparticles (IONPs) have been proposed as agents for magnetic resonance imaging (MRI), localized hyperthermia treatment, controlled drug release, and magnetic guidance and manipulation [1,2,3,4,5,6]
20 nm NCs were selected for realizing assemblies of nanocubes (ANCs) coated either with a double OA layer or with bovine serum albumin (BSA)
The BSA-ANCs exhibited the longest stability under physiological conditions, with an average hydrodynamic diameter of about 100 nm, stable for at least seven days
Summary
Iron oxide nanoparticles (IONPs) have been proposed as agents for magnetic resonance imaging (MRI), localized hyperthermia treatment, controlled drug release, and magnetic guidance and manipulation [1,2,3,4,5,6]. Localized hyperthermia and tissue thermal ablation can be achieved by exposing IONPs to alternating magnetic fields (AMFs) for sufficiently long periods of time [8,9,10]. Several reports have shown that IONPs are biodegradable, and that the dissolved iron can participate in the physiological metabolism of cells, limiting possible toxicity concerns and supporting repetitive use [12,13]. Their intrinsic theranostic properties, biocompatibility, and biodegradability have contributed to the popularity and success of IONPs in biomedical applications
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
