Abstract
Recombinant vaccinia viruses that express a full-length Hepatitis C virus (HCV) genome were constructed. Chimpanzee liver cells were infected with the recombinant viruses and analyzed by electron and immunoelectron microscopy. Three kinds of structures specific to recombinant HCV vaccinia infection were found in the cytoplasm of the infected cells. They are virus-like particles, clustered particles and high density reticular structures, the latter two of which are often fused together, indicating that they are related each other. Monoclonal antibodies against core, envelope and NSl and human HCV antisera clearly stained the reticular structures, indicating that at least the reticular structures and perhaps the clustered particles are derived from HCV proteins.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
