Abstract
In the biosynthesis of polyketides, Nature takes a simple building block and through a series of iterative enzymatic reactions [polyketide synthases (PKS)] manufactures a vast array of secondary metabolites, many of which display high chemical complexity and biological activity. We propose to try to emulate Nature’s remarkable structural and functional diversity in assembly of polyketides through a related strategy. In particular we have taken simple boronic esters and carried out iterative homologations using primary and secondary lithiated carbamates, enabling us to grow carbon chains with control over both relative and absolute stereochemistry. Applications of this strategy to natural and non-natural products will be demonstrated.
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