Abstract
Eukaryotic cells contain many types of ribonucleoproteins (RNPs) which are complexes formed by RNA molecules associated with proteins. The majority of these RNPs are in the nucleus and can be classified in two groups, the small nuclear RNPs (snRNPs) that function in the maturation of messenger RNAs, and the small nucleolar RNPs that reside in the cell nucleolus and are required for maturation of ribosomal RNAs. Although both types of RNPs function in two different fundamental processes, progress made during the last few years shows that their assembly requires similar protein components. This review focuses on the factors and mechanisms governing snRNPs and snoRNPs biogenesis as well as on the mechanisms implicated in the sorting of these RNPs to their intracellular destinations.
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