Abstract
BackgroundPathogenic fungi often cause serious infections mainly in immunocompromised persons. The number of infections caused by the non-albicans Candida or other species has significantly increased over the last years. These infections present a major challenge in the health sector because these pathogenic fungi have strong virulence and often show resistance to the commonly used antifungal treatments. To solve the problems caused by the drug resistant pathogenic fungi, it is necessary to find new antifungal agents and their sources. The aim of this study was to give evidence that yeasts can effectively fight against strains which belong to pathogenic fungi and reveal those yeasts which are able to inhibit growth of Kodamaea ohmeri, Pichia kudriavzevii, Naganishia albida or Candida tropicalis. Furthermore, we wanted to determine the effects of certain culturing factors on the growth inhibition.ResultsOur screening revealed that although the strains belonging to pathogenic species were much more tolerant to the yeast-produced bioactive agents than the non-disease-associated yeasts, growth of Kodamaea ohmeri and Candida tropicalis could be inhibited by Metschnikowia andauensis, while Naganishia albida could be controlled by Pichia anomala or Candida tropicalis. Our data proved that the experimental circumstances could have a serious impact on the inhibitory capacity of the yeasts. Appearance of inhibition strongly depended on media, pH and temperature. Our data also shed some light on the fact that Pichia kudriavzevii must have high natural resistance to the yeast-produced agents, while other species, such as Saccharomycopsis crataegensis belonged to the easily inhibitable species.ConclusionsOur study suggests that yeast-produced bioactive agents could be potential growth inhibitory agents against the disease-associated fungi and yeasts can also contribute to alternative approaches to combat against pathogenic fungi. Our data revealed an important role of the culturing factors in inhibition and pointed to the complex nature of antagonism.
Highlights
Pathogenic fungi often cause serious infections mainly in immunocompromised persons
Growth of Kodamaea ohmeri, Candida tropicalis and Naganishia albida cells could be inhibited by yeast species In order to find yeast species which are able to inhibit cell division of the strains belonging to disease-associated species, several yeasts were investigated
Our results showed that growth of Kodamaea ohmeri (Fig. 1a) and Candida tropicalis could be inhibited by M. andauensis cells, while Naganishia albida was controlled by P. anomala and C. tropicalis (Table 1)(indicated with +)
Summary
Pathogenic fungi often cause serious infections mainly in immunocompromised persons. The number of infections caused by the non-albicans Candida or other species has significantly increased over the last years. The aim of this study was to give evidence that yeasts can effectively fight against strains which belong to pathogenic fungi and reveal those yeasts which are able to inhibit growth of Kodamaea ohmeri, Pichia kudriavzevii, Naganishia albida or Candida tropicalis. Studies have demonstrated that fungal sepsis can quite often be caused by non-albicans Candida or other species, such as Candida tropicalis, Pichia kudriavzevii (synonyme Candida krusei), Kodamaea ohmeri (synonyme Candida guillermondii) cells or Naganishia albida (formerly Cryptococcus albidus) ([1, 2], reviewed in [3,4,5,6,7,8,9]). Naganishia albida was isolated from transplant recipients or lesions ([8], reviewed in [9])
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