Abstract
Assay to Detect H5N1 Oseltamivir Resistance
Highlights
To the Editor: Oseltamivir is a neuraminidase inhibitor approved for treatment and prevention of influenza virus infection
Oseltamivir resistance caused by a single amino acid substitution from histidine (H) to tyrosine (Y) at position 274 of the neuraminidase active site has been reported in persons infected both experimentally and naturally with influenza A virus subtype H5N1 [1,2]
Evidence suggests that using lower doses of oseltamivir or shorter-than-recommended treatment periods can contribute to emergence of viral resistance [1,3] Currently, oseltamivir is being used in several countries that may be affected by epidemics of H5N1
Summary
To the Editor: Oseltamivir is a neuraminidase inhibitor approved for treatment and prevention of influenza virus infection. Oseltamivir resistance caused by a single amino acid substitution from histidine (H) to tyrosine (Y) at position 274 of the neuraminidase active site has been reported in persons infected both experimentally and naturally with influenza A virus subtype H5N1 [1,2]. To discriminate between oseltamivirsensitive and oseltamivir-resistant strains, we developed a simple method, based on PCR, which takes advantage of the H274Y substitution.
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