Abstract
Comparison of USP method for the assay of quinacrine hydrochloride involving precipitation of the dichromate salt and determination of the excess dichromate with the nonaqueous titration using a visual end point and a proposed nonaqueous titration with a potentiometric end point, shows that all three methods give the same results, with the nonaqueous methods superior in reproducibility and rapidity. The proposed method is also satisfactorily applied to the assay of quinacrine hydrochloride tablets.
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