Abstract
INTRAPERITONEAL injection of 5-hydroxytryptophan (5HTP) shortly before death causes a considerable post-mortem rise of 5-hydroxytryptamine (5HT) in the brain of rats. This may be explained by the fact that 5HTP decarboxylation continues during the first few hours post-mortem whereas monoamine degradation by monoamine oxidase is probably considerably reduced1. In the work reported here the question was investigated whether this 5HTP induced post-mortem increase of brain 5HT might be used as a test for decarboxylase inhibitions. D,L-α-Methyl dihydroxyphenylalanine (α-methyl DOPA)2–6 served as a model inhibitor.
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