Abstract
Numerous methods have been published for the determination of disulfiram (DSSD) and its metabolites in biological material. The very multiplicity of published methods, most of which have been used subsequently only by their authors, if at all, is indicative of the difficulties inherent to the problem. Brien and Loomis (1983a) have written a comprehensive and detailed review of this subject. Accordingly, this chapter deals first with a discussion of overriding issues; secondly, with methods deemed noteworthy because of their inherent advantages, and thirdly with such other methods as were used in measuring the plasma levels of DSSD and metabolites, values from which the pharmacokinetic parameters listed in the tables of Chapter 7 were computed.
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